(68g) Engineering Protein Assemblies for Energy and Health

Wen, F., University of Michigan
Over more than 500 million years of evolution, nature has relied on the cooperation of functionally related proteins to perform complex tasks in all life forms ranging from unicellular organisms to human. Harnessing this functional cooperativity remains a grand challenge in synthetic biology. In the past two decades, by focusing on the engineering of single target proteins, a great number of value-added natural and unnatural proteins have been successfully generated and commercialized, such as monoclonal antibodies, industrial enzymes, protein pharmaceuticals, etc. Looking forward to address challenges in more complex systems, the next generation protein engineering strategies that focus on the cooperative function by bringing related proteins together to form assemblies are desired. In this presentation, I will discuss how these novel strategies will lead to enabling technologies in sustainable energy and human health, especially with respect to cooperative catalysis and immunotherapy.