(652c) 3D Printed Absorber for Capturing Chemotherapy Drugs before They Are Released in the Body

Authors: 
Oh, H. J., University of California, Berkeley
Aboian, M., University of California, San Francisco
Yi, M., University of California, Berkeley
Maslyn, J., Lawrence Berkeley National Laboratory
Loo, W., University of California, Berkeley
Parkinson, D., Lawrence Berkeley National Laboratory
Moore, T., University of California, San Francisco, California
Wilson, M., University of California, San Francisco, California
Robbins, G., Carbon, Inc.
Barth, F., Carbon, Inc.
Yee, C., University of California, San Francisco, California
DeSimone, J. M., University of North Carolina at Chapel Hill
Hetts, S. W., University of California, San Francisco
Balsara, N. P., University of California, Berkeley
Jiang, X., Lawrence Berkeley National Laboratory
Cancer is becoming the leading cause of death in most westernized nations. Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. During intra-arterial chemotherapy infusion to a target organ, excess drug that is not trapped in the target organ passes through to the veins draining the organ, and is then circulated to the rest of the body, causing toxicities in distant locations. Typically, more than 50-80% of the injected drug is not trapped in the target organ and bypasses the tumor to general circulation.

In this context, we have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the blood stream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The porosity was obtained by 3D printing of lattice structures within a cylinder. The surface of porous cylinders was coated with an ion-containing polymer which is responsible for capturing doxorubicin, a widely used chemotherapy drug with significant toxic side effects. Using a swine model, we show that our initial design enables the capture of 69 % of the administered drug without any immediate adverse effects. Additional improvement in performance may be obtained by changing the chemical composition and thickness of the coating layer, in addition to controlling the lattice structure and size with elastomers. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.