(429e) Integration of Heuristic Knowledge in a Skin-Care Emulsion Design
Here we illustrate the CAMD methodology integrated with heuristics and its use in the cosmetic emulsions design, using a body lotion as an example. Initially, the general structure of the methodology is presented; then, the heuristics regarding formulation and manufacture, the selected performance parameters for this kind of products, and the details of the experimental validation are described. The results show that the incorporation of heuristics into a systematic CAMD methodology using integer programming with logical constraints enables to obtain a set of feasible alternatives, which are optimised to meet the specified requirements of performance with a minimal cost. The obtained emulsion design was validated by developing and manufacturing a set of body lotion samples. The rheological, textural and microstructural properties of the samples, along with their consumer assessment, show that these alternatives met the expected properties. This methodology could be used as a rapid preliminary design tool for inexperienced cosmetic scientists and designers. Also it can help to reduce the time and resources spent in cosmetic emulsions design, comparing with the traditional trial-and-error methods.
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