(427f) Solubility of Lanosterol in Organic Solvents
Lanosterol is a sterol derivative that plays a key role in the biosynthesis pathway of cholesterol. Recently, it has been found to reverse the formation of cataracts. The physicochemical properties of lanosterol are poorly understood. Pure lanosterol (>95%) was isolated from a raw product (54.6%) by a newly developed c18 reverse-phase high-performance liquid chromatography (HPLC) method. Purity and structure were confirmed by gas chromatographyâmass spectrometry (GC-MS).Ultravioletâvisible spectroscopy shows lanosterol has a maximum absorption peak at 213 nm and an extinction coefficient 77000M-1cm-1. The fusion enthalpy and melting point determined by differential scanning calorimeter are 38.5kJâmol-1 and 404.25 K, respectively. The solubility of lanosterol was measured in methanol, ethanol, acetonitrile, acetone and ethylene acetate using a static equilibrium set up in the temperature range from 290.6 K to 320.8 K. The solubility of lanosterol increases with the increase of temperature and decreases with increasing the polarity of solvents. The solubility of lanosterol has a minimum of 0.11molâL-1 in acetonitrile at 291.6 K and a maximum of 1.27molâL-1 in ethylene acetate at 320.8 K. Furthermore, the solubility of lanosterol in petrolatum at the same temperature range was extrapolated from a binary mixture of toluene and petrolatum. Single solvent data were fitted by the modified Apelblat equation and UNIFAC was used to fit binary mixture data.
This paper has an Extended Abstract file available; you must purchase the conference proceedings to access it.
Do you already own this?
Log In for instructions on accessing this content.
|AIChE Graduate Student Members||Free|
|AIChE Undergraduate Student Members||Free|