(420d) Biofunctionalization of Implants through Thin Films

Control of the tissue-implant interface is integral to the success of the implant, and ultimately the health of the patient. Through a series of projects on multiple types of implant substrates, the Gawalt Lab has developed a system for immobilizing multiple bioactive molecules on the surface to control the interface using strongly adhered linkers and basic organic chemistry. For example, ceramic surfaces have been modified as bone fillers to enhance bone growth and reduce infection with either one or two molecules, while stent materials are being modified to reduce platelet aggregation and stimulate endothelization. Recently, a triple-functionalized surface has been completed on orthopedic implant materials to simultaneously enhance bone growth, while reducing bacterial adhesion. This new system is the first system with three bioactive molecules in a coating.