(402f) Exploring Mesoporous Supports As a Means to Separate Physical Property Control from Crystallization

Authors: 
Polster, C. S. - Presenter, Eli Lilly and Company
Burt, J., Eli Lilly and Company
Merritt, J., Eli Lilly and Company
Polizzi, M., Eli Lilly and Co
Greenwood, D. E., Eli Lilly and Co
Aburub, A., Eli Lilly and Co
Mesoporous supports have been explored previously as carriers for API. Often, they are used for their crystallization inhibiting abilities in order to isolate and stabilize an amorphous state. The amorphous state is intended to improve in vivo performance and bioavailability. This work describes the use of incipient wetness impregnation as a method to prepare API/mesoporous composites. The methodology is proposed as a highly scalable manufacturing platform and thus a lean development approach. Examples of API candidates are discussed, including physical/chemical stability, powder physical properties and tableting properties of the composites. A holistic strategy for implementing this approach in drug development will be presented.