(328b) Autonomous Reaction Platform for Continuous Chemical Synthesis
- Conference: AIChE Annual Meeting
- Year: 2018
- Proceeding: 2018 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Tuesday, October 30, 2018 - 12:52pm-1:14pm
Our research has focused on the development of a continuous flow chemistry platform capable of multi-step syntheses, and robotic reconfigurability. Our talk will discuss, the integration of a library of flow chemistry modules capable of handling solids, aggressive reagents, inline separations and the intense reaction conditions required for organic synthesis. The system is designed to assemble modules and fluidic connections into a continuous flow process. The assembly of the system is coordinated through a web-based interface which generates reaction recipes and can be connected to a synthetic route planning software. Our platform has been used to rapidly synthesize a variety of active pharmaceutical ingredients (API) and dyes requiring stereoselectivity, site-selectivity, library generation, and convergent synthesis. Through the development of flexible process modules, our integrated robotic platform aims to decrease the time required to synthesizing new molecules while increasing synthetic repeatability and lab-to-lab transferability. Automation of synthetic chemistry can decrease the time for molecule development and allow chemists to focus on pathway refinement, reaction optimization, and process analytics.