(289e) Transport of Paramagnetic Nanoparticles in Magnetic Field for Drug Delivery
- Conference: AIChE Annual Meeting
- Year: 2018
- Proceeding: 2018 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Tuesday, October 30, 2018 - 9:40am-10:00am
Paramagnetic particles can be used as carriers to effectively transport drugs through cerebrospinal fluid and deliver to the targets using a magnetic field. Since the invivo experiments are expensive and difficult to conduct for such systems, a mechanistic model that can predict the dynamics and distribution of paramagnetic particles is necessary for the optimal design of drug delivery systems. The existing models are applicable to dilute solutions of paramagnetic particles and cannot be extended to concentrated solution, which is generally created near the magnetic targets. In this talk, I will present a framework to model magnetophoretic diffusion and convection of paramagnetic particles in a concentrated solution. An analytical solution to the magnetic field-driven transport of particles in 1-D will be discussed with application to drug delivery through cerebrospinal fluid.