(200w) Development and Scale-up of a Robust Impinging Jet Process Under GMP Conditions
AIChE Annual Meeting
Monday, October 29, 2018 - 3:30pm to 5:00pm
To address the formation of a problematic dimer impurity in a mixing sensitive reaction network, an impinging jet flow process was developed to be used under GMP conditions. Efficient process development of the robustness of the impinging jet required an intricate understanding of the kinetics, transport phenomena, and analysis of flow patterns within these jets. Rational exploration of these factors enabled us to scale-up this process to process multi-kilogram amount of API.
The work presented here was sponsored by AbbVie. AbbVie contributed to the design, research, and interpretation of data, writing, reviewing, and approving the presentation. All authors are employees of AbbVie.