(200l) Multi-Stage and Multi-Objective Design Tool for Process Design in Sterile Filling of Biopharmaceuticals
- Conference: AIChE Annual Meeting
- Year: 2018
- Proceeding: 2018 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Monday, October 29, 2018 - 3:30pm-5:00pm
In this work, we present a multi-objective decision-making tool for sterile filling of biopharmaceuticals that can be used across multiple design stages. The basis of the work is the evaluation models developed by the authors to compare SUT and MUT in terms of the economic performance, environmental impacts, product quality, and supply robustness. The weighting factors of design objectives were defined for aggregating multi-objective evaluation results, where sensitivity analysis of the factors were conducted within the possible combinations. We will conduct a questionnaire survey to industrial practitioners, and the results can be used to set the weighting factors and provide a solution that best fits the users. Also, the tool will provide rigorous and tailored solutions across design stages by varying underlying model complexities in accordance to user requirements and available data at each design stage. The tool will be supported by data collected through industrial databases and expert knowledge. We aim to implement the tool in the form of a web-based application to enhance the practicability of the design tool for the users.