(200af) Dropwise Manufacturing of Oral Solid Dosage Forms Using Powder Slurries
- Conference: AIChE Annual Meeting
- Year: 2018
- Proceeding: 2018 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Monday, October 29, 2018 - 3:30pm-5:00pm
In this work, a dropwise manufacturing platform is used to produce high dose drug products using concentrated suspensions of non-Brownian particles. Pharmaceutical powders are selected based on achievable particle sizes (1-500µm) from controlled crystallization unit operations, and suspensions are formed with volatile/non-volatile carrier liquids for delivery onto suitable substrates by dropwise addition. The resultant solid oral dosages are analyzed for their mass/composition content uniformity and for the extent of preservation of particle size distribution before/after printing. Process performance metrics for dropwise manufacture of solid oral dosage forms using particle suspensions are presented in terms of drop volume/mass statistics and process throughput (number of doses per unit time); the effects of suspension properties (e.g. particle loading, particle size) on drop volume/mass and process throughput are clarified using the rheological behavior observed through high speed photography of the drop formation process .
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