(192j) Modelling of Vessel Molar Transport Under Mural Electrical Field Gradient

Jillian G. Arnold; Chloe P. Winter; Mathias A. Oyanader and Mario A. Oyanader

Chemical Engineering Departments, California Baptist University, 8432 Magnolia Ave. Riverside, CA 92504, E-mail: moyanader@calbaptist.edu

The vascular system can be seen as the super highway for the transportation of biomolecules and other less complex chemicals. Blood being the carrier fluid requires special attention since is non Newtonian in behavior. For this reason is that the modeling on blood and other non-Newtonian fluids has been revised continuously over the past few decades. Despites the efforts, it is still uncertain how electrical fields moderate the mass transport in the vascular system. An exploratory investigation on the subject is needed from a fundamental analysis approach. In this contribution, the focus is on the analysis of the impact of electrical field gradient, applied on the capillary wall, on vessel concentrations. For the study, the molar species continuity equation coupled with a Power Law model for the shear stress constitutes the governing fundamental equation solved analytically. In addition, vessel concentration prediction and comparison to see potential influence on drug concentration profile is illustrated. A summary these results will be provided with important insights into the development and implications to new treatment protocols for patients with vascular diseases. The influence of different order of magnitude of the electrical fields has been also studied to assess potential enhancement of drug delivery application. The influence of blood shear thinning characteristics have also been investigated and illustrative results will be presented in the analysis.