Electrospinning and Degradation of Poly(lactic-co-glycolic acid) (PLGA) As a Potential Wound Healing Dressings

Chronic wounds affect more than 6.5 million people in United States with expenditures of more than 25 billion dollars for treatments and other interventions. In spite of this, a significant amount of cases have bad prognoses, of which a majority lead to amputations. The objective of this research is to fabricate poly(lactic-co-glycolic acid) (PLGA) electrospun fibrous mats, study the degradation kinetics in phosphate-buffered saline, and analyze the time-dependent release of therapeutics with potential applications for wound healing. The fibrous mats can be used as wound dressings, which provide excellent mechanical support for cell migration, tissue growth, and as an agent of local drug delivery.