(767c) Peptoid-Grafted Hollow Fiber Membranes for Improved Biocompatibility

Biofouling is a persistent problem for membranes exposed to blood or other bodily fluids, affecting membrane surface structure and hindering performance. In this work, we demonstrate that polysulfone (PSU) hollow fiber membranes that are grafted with peptoids containing methoxyethyl (NMEG) side chains resist nonspecific protein adsorption. NMEG was attached to surface via polydopamine (PDA). The modified surfaces were characterized to determine grafting density, contact angle, strength, pore size, and smoothness. The long-term stability of the peptoid-modified hollow fibers was confirmed over six months. Peptoid-grafted PSU has increased hydrophilicity compared to unmodified PSU and comparable mechanical stability. The peptoid-grafted hollow fibers had reduced adsorption of single proteins (bovine serum albumin, lysozyme and fibrinogen). Additionally, the effect of side chain length and grafting density on protein adsorption was evaluated. It was determined that there is an optimal grafting density for reduction of protein adsorption, which was dependent on the length of the peptoid. These studies show that peptoid-grafted PSU membraned provide a low-fouling surface with improved biocompatibility for use in biomedical and blood-contacting applications.