(729a) Peptide-Appended HybridArenes Are Artificial Water Channels with High Permeability and Selectivity
The development of new artificial water channels that mimic aquaporins has gained increased interest in recent years, particularly due to the ever increasing global demands on pure water supply. Criteria for development of advanced water channels can be considered as: 1) water permeability, 2) selectivity and 3) feasibility of commercialization. Several candidates have been suggested but none of them have substantially satisfied the above standards, including aquaporin proteins, carbon nanotubes and current synthetic water channels. Here, we propose new version of artificial water channel, peptide-appended hybridarenes (PAH). Our experimental data showed PAHâs single channel water permeability at 2.3(Â±1.1)Ã109 water molecules per second which is comparable with those of aquaporinâs (0.34~4.03Ã109 water molecules per second), in addition to significant sodium chloride rejection (~100%). Based on these results, PAH is highly expected to have an ideal pore structure in terms of water permeability and monovalent ion selectivity. Furthermore, since this artificial channels has outstanding compatibility with various organic solvents, PAH is believed to meet above mentioned qualifications for a promising candidate to develop reverse osmosis membranes based on artificial water channels.