(71a) Automated Systems for Screening, Kinetics, and Optimization of Chemical Synthesis and On Demand Production
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Monday, October 30, 2017 - 8:05am-8:50am
As an example of process integration for on demand manufacturing, we present a plug-and-play, reconfigurable, refrigerator-sized manufacturing platform for on-demand synthesis of common pharmaceuticals, e.g. ciprofloxacin.This flexible system is capable of complex multi-step synthesis, in-line purification, post-synthesis work-up and formulation. Multistep synthesis occurs at elevated temperatures and pressures to enhance reaction rates, and the resulting residence times are a few minutes, in contrast to the multiple hour-long synthesis typically needed for batch. Typical production rates are grams/hour sufficient to produce thousands of doses per day of common pharmaceuticals. Finally, we discuss opportunities for integration of machine learning for synthesis planning with fully automated chemical synthesis systems.