(717a) Oral Formulations: Perspectives from Additive Manufacturing
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Thursday, November 2, 2017 - 12:30pm-12:51pm
The manufacture of multiple capsule-based formulations using non-colloidal particulate suspensions is presented in this study. Particles selected from micronized and non-micronized powder grades are characterized in terms of particle size and bulk powder properties, which, in concert with rheology experiments are used to guide printing fluid formulations. Quantitative measures of product physical properties and respective production rates are presented for four active substances in 1-100 milligram amounts, delivered by hydro-philic/phobic carrier fluid platforms. Based on these results, perspectives are given on the ability of the platforms to complement current formulation selection strategies for BCS Class I and Class II drugs and on the potential for the technology serve at both the personalized medicine and industrial manufacturing scales.
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