(623f) Direct Co-Crystal Assembly from Synthesis to Co-Crystallization
AIChE Annual Meeting
2017
2017 Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Process Intensification and Advanced Control of Pharmaceutical Processes
Wednesday, November 1, 2017 - 5:00pm to 5:21pm
Pharmaceutical co-crystals were assembled directly via chemical synthesis by cooling under three new strategies. The screening method for direct co-crystal assembly by a chemical reaction was developed based on liquid-assisted grinding. The ternary phase diagram including a chemical reaction and co-crystallization was established for a 2 : 1 co-crystal of benzoic acidâsodium benzoate.