(612d) Optimal Crystal Size Control Using a Continuous Plug Flow Crystallization Configuration with Recycle
AIChE Annual Meeting
2017
2017 Annual Meeting
Separations Division
Modeling and Control of Crystallization
Wednesday, November 1, 2017 - 4:20pm to 4:40pm
Motivated by [2], the novel mathematica models were provided in [3]. Consequently, the jacket temperatures and the superficial velocity were studied and optimized to realize the control of the crystal size and shape distributions throughout PFC system.
Motivated by the above, in the present work, we are considering simultaneously the optimal design and control for the continuous PFC system to achieve the high yield, the low equipment costs and the desired crystal size distribution. In particular, the method of moment is applied to the population balance model to derive a reduced-order moment model. First, based on the steady-state models, design variables for the recycle-type PFC such as tubing lengths, the extraction position and jacket temperatures for each segment of the PFC are analyzed and optimized to minimize experimental equipment costs and maximize the yield, while ensuring the desired crystal sizes. Then, the dynamic mathematic models for crystal concentrations, PFC temperatures and crystal populations are involved. Given the designed PFC configuration, the jacket temperatures, the superficial velocity and the recycling ratio are investigated and optimized in order to minimize the squared deviation of the average crystal size from the set-points throughout the PFC.
[1] Cogoni, Giuseppi, B. P. de Souza, and Patrick J. Frawley. ``Particle Size Distribution and yield control in continuous Plug Flow Crystallizers with recycle." Chemical Engineering Science 138 (2015): 592-599.
[2] Liu, Jing J., Yang D. Hu, and Xue Z. Wang. ``Optimization and control of crystal shape and size in protein crystallization process." Computers & Chemical Engineering 57 (2013): 133-140.
[3] Kwon, Joseph Sang-Il, et al. ``Crystal shape and size control using a plug flow crystallization configuration." Chemical Engineering Science 119 (2014): 30-39.
Checkout
This paper has an Extended Abstract file available; you must purchase the conference proceedings to access it.
Do you already own this?
Log In for instructions on accessing this content.
Pricing
Individuals
AIChE Pro Members | $150.00 |
AIChE Graduate Student Members | Free |
AIChE Undergraduate Student Members | Free |
AIChE Explorer Members | $225.00 |
Non-Members | $225.00 |