(567f) Fast Mixing, Ketimine Additions, and the Application of Flow Chemistry to Verubecestat
AIChE Annual Meeting
Wednesday, November 1, 2017 - 2:05pm to 2:24pm
During the commercial route development of MK-8931, it was determined that the nucleophilic addition to an imine could be improved by performing the reaction in flow. The enhanced mixing lead to an increase in the yield of the reaction while excellent heat transfer properties of a flow reactor lead to the elimination of the need for cryogenic conditions.
The development of this process from an initial lab scale hit through a successful demonstration in the prep lab at multi kilogram scale to a pilot plant campaign on hundreds of kilograms is presented.