(476a) Immunomodulatory Peptide Amphiphile Micelles for Prophylactic Vaccination
AIChE Annual Meeting
2017 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Drug Delivery I
Wednesday, November 1, 2017 - 8:00am to 8:18am
This study demonstrates that micelle vaccinesâ physical properties such as size, shape, and surface charge are controllable by chemical modification. These different physical properties have shown different abilities to interact with biological systems. For instance, these interactions include different cell uptake ability by Antigen Presenting Cells(APCs), immunogenicity, and cytotoxicity. These discoveries will help the future design of prophylactic vaccines.
Vaccine adjuvants are vaccine agonists that can help the body produce protection. Molecular adjuvants are a type of adjuvants that can stimulate Toll Like Receptors (TLRs) on APCs. Studies have shown that co-delivery of antigen and adjuvants can produce desirable immune responses, so numerous research has been done to associate antigen and molecular adjuvant utilizing engineering methods. This study compares two co-delivery strategies of the model ovalbumin antigen peptide and the TLR-2 agonist Pam2C, a lipid based adjuvant, either chemically linking with Pam2C and antigen to form micelles (strong association force), or entrap Pam2C in antigen micelles (weaker association force). Surprisingly, the stronger chemical association between antigen and Pam2C yielded lower immunogenicity both in vitro and in vivo. This may lead to more extensive studies on the topic of the co-delivery of antigen and adjuvant for vaccine research.