(443b) Assessing the Impact of Dry Coating on the Surface Properties of Pharmaceutical Formulations
AIChE Annual Meeting
Tuesday, October 31, 2017 - 3:36pm to 3:57pm
This work proposes the use of vibrations for the efficient dry coating of materials of pharmaceutical interest with silica nanopowder.4 The API or excipient of interest are placed in a jar, attached on a shaker, along with different loadings of silica nanopowder. The vibrations created by the shaker lead to the efficient coating. The coating efficiency is examined using SEM. The influence of particle habit and surface anisotropy on the efficiency of the coating was, also, investigated.
Inverse gas chromatography (IGC) was employed to provide an in depth understanding on the influence of coating on the surface properties of the particles. The surface energy of the coated particles, measured with IGC, decreases abruptly in the presence of relative humidity. For measurements conducted at RH>30 %, the surface energy measured was effectively the same. This suggests that the interactions were mainly driven by the presence of a water layer on the particles. Furthermore, IGC experiments were used to assess the roughness of the coated particles.5 The measurements suggest that higher shaking times lead to a more rough area, associated with better flowability.
This study proposes an efficient, compact and moving parts-free dry coating process. It examines the influence of particle properties on dry coating and furthermore it employs vapour sorption tools to examine the roots of the improved behaviour of particles coated with nanopowders.
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