(401au) Adsorption Rate Constant and Equilibrium Constant in Chiral Separation for Trans-Stilbene Oxide, Linalool and Ibuprofen By Supercritical Fluid Chromatography
As a result, the adsorption equilibrium constant KA, defined as the rate constant ratio of desorption kd to adsorption ka were almost constant, independent of the flow rate of the mobile phase. On the other hand, the adsorption rate constant ka can be approximated by a linear curve passing through the origin and it can be said that there is a tendency to depend strongly on the flow velocity with correlation coefficients R2 = 0.99 or higher. As the flow velocity increases, since the number of analyte molecules adsorbing and desorbing passing through the silica gel surface increased, this resulted in increasing ka and kd. Thus, KA did not depend on the flow rate and were almost constant for each component.
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