(373e) Moving Horizon Based Real Time Optimization and Hybrid Control of Continuous Pharmaceutical Manufacturing Process
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
- Time: Tuesday, October 31, 2017 - 1:58pm-2:20pm
In this work, a moving horizon based real time optimization (MH-RTO1) technique has been integrated with a hybrid model predictive control (MPC) system for a continuous downstream separation and purification process of Active Pharmaceutical Ingredients (API). The integrated process flowsheet consists of four continuous downstream unit operations (Crystallization, filtration, drying and mixing). In the proposed approach, the integrated MH-RTO provides the optimal operational set points for the total production rate in real time. The MH-RTO takes into consideration the capital and operating cost, the market fluctuations, the product inventory, the product quality assurance strategy, the regulatory constraints, and the product rejections. An advanced hybrid model predictive control system then ensures that required production rate with desired quality is met with minimum resources and time. A robust optimization strategy and an efficient control system have been integrated to achieve the maximum profit. The MH-RTO integrated with a hybrid control strategy ensures the maximum possible profit irrespective of the market demand fluctuations. The basic advantage of the MH-RTO framework is that it takes into consideration the future demand as well as past inventory and thus can lead to increased profit compared to a standard Real Time Optimization (RTO) or optimization free approaches.
The objective of this presentation is two-fold. First to highlight the moving horizon based real time optimization technique and MPC-PID hybrid control architecture, and second to demonstrate the real time optimization and control of continuous downstream API purification and separation process.
. Singh, R., Sen, M., Ierapetritou, M., Ramachandran, R. (2015). Integrated moving horizon based dynamic real time optimization and hybrid MPC-PID control of a direct compaction continuous tablet manufacturing process. Journal of Pharmaceutical Innovation, 10 (3), 233-253.