(299f) Toward Efficient Development and Reliable Scale-up of Agitated Filter Drying Protocol through DEM Modeling and Simulation
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Tuesday, October 31, 2017 - 10:05am-10:30am
Gradual evolution of powder bed during the drying results in continuously changing physical properties. This poses significant challenges in experimentally driven understanding of the impact of drying process parameters on final physical properties. Agglomeration and attrition, which are governed by the shear, are the major issues encountered during design and scale-up of filter drying operation. The extent of shear and its distribution changes significantly across various scales and is not amenable to experimental measurements. With advancements in computer algorithms and cheaper computational power, more fundamental insights into particle dynamics including the shear stress distribution can be assessed using Discrete Element Methods (DEM).
In this talk, we will present some of the key attributes that govern the particle dynamics calculated using DEM in the context of AFD operation. We will also provide a decision tree to guide efficient design and reliable scale-up of agitated filter drying.