(203l) PAT on Oscillatory Systems: Monitor and Control Continuous Crystallization with Fourier Transform Infrared (FTIR) Spectrometer
- Conference: AIChE Annual Meeting
- Year: 2017
- Proceeding: 2017 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Monday, October 30, 2017 - 3:15pm-4:45pm
A model-free control strategy for continuous cooling crystallization of paracetamol in the OBR is implemented in this study. Supersaturation control (SSC) is a model-free technique where concentration is monitored and supersaturation level is controlled by adjusting operating conditions such as temperature for the case of cooling crystallization. SSC has been well studied in MSMPR systems.8,9 An SSC implementation was carried out for continuous crystallization in the OBR via CryMOCO, a commercially available integrated control software, a Huber thermo-regulator with a temperature sensor and a FTIR spectrometer. The FTIR is equipped with the Interferogram correcting the signal interference from oscillations. It provides online measurements of solute concentration in solution used by CryMOCO to control supersaturation. This study serves as a proof-of-concept for continuous crystallization SSC control in oscillatory systems.
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