(197d) Overcoming Obstacles to Brain Repair Using Biomaterials
Research in my laboratory overÂ the past decade has focused on the generation of hydrogel biomaterials toÂ support the formation of a reparative niche withinÂ diseased or injured sitesÂ that can block or prevent inhibitory signals from dominating the repairÂ process, while providing pro-repair signals that can guide new tissueÂ formation. The goal of our approach is to use engineered materials to âunlockâÂ the regenerative capacity of damaged or diseased tissue to promote repair. TheÂ premise of our approach is that all tissues in the body have the capacity toÂ repair through local stem or progenitor cells, but that due to unfavorableÂ environmentalÂ conditions during the normal healing process they are not able toÂ do so. In this talk, I will describe our approach to overcome physical andÂ chemical barriers to brainÂ repair after stroke using biomaterials.