Citrate-Based Macromolecules: A Versatile Biomaterial Platform for Regenerative Engineering

Advances in biomaterials science and engineering are crucial to solving complex medical problems that involve the replacement, repair, or regeneration of tissues and organs. Our laboratory pioneered the development and applications of citrate-based macromolecules (CBMs). CBMs can be engineered to exhibit physical, chemical, and biological functionalities that are suitable to solving a variety of medical problems and potentially treating disease conditions in the circulatory, musculoskeletal, renal, intergumentary (skin), and endocrine systems. I will discuss the properties of CBMs and fundamental design strategies that render them a powerful biomaterial platform for cell delivery, wound healing, and regenerative engineering applications.