(671d) Additive Manufacturing of Multicompenent Biomaterials
AIChE Annual Meeting
Thursday, November 17, 2016 - 1:24pm to 1:42pm
Additive manufacturing, including 3D printing and 3D bio-printing, are enabling the prototyping and production of geometrically-defined and patient specific biomaterials.1 Despite the many recent advances in additive manufacturing technologies,2,3 there remains limitations in the speed of production, access to a broad range of materials, and easy integration of multiple materials and cells within a single device. Here, we present a facile manner to produce rapidly multicomponent biomaterials with defined geometry incorporating both structural and mechanical support from polymeric constituents (e.g., (meth)acrylates, polycaprolactone, poly(lactic-co-glycolic acid)) as well as cellular and tissue integration from hydrogels (e.g., poly(ethylene glycol) based, collagen/elastin based, gelatin methacryloyl based). This process integrates the benefits of additive manufacturing with the benefits of hydrogel biomaterials by enabling cell-laden biomaterials with defined structure and mechanical integrity. In addition, the process can access a variety of applications on account of its scalability and versatility. We demonstrate the efficacy of this approach to fabricate cell-laden biomaterials for ex vivo models of functional tissue as well as for on scale tissues for regenerative medicine applications. Overall, this presentation will present a facile process of multicomponent biomaterial fabrication and illustrate how this contributes to the emerging field of additive manufacturing in biotechnology and medicine.
- Murphy SV et al. Nat Biotech 32 (2014) 773-785
- Appel EA et al. Chem Soc Rev 107 (2010) 18392-18397
- Kang HW et al. Nat Biotech 34 (2016) 312-319