(652d) Probing Sub-Cellular Organelle Contents with Carbon Nanotube Optical Reporters
AIChE Annual Meeting
2016 AIChE Annual Meeting
Nanoscale Science and Engineering Forum
Nanotechnology and Nanobiotechnology for Sensors and Imaging I
Thursday, November 17, 2016 - 9:24am to 9:42am
The optical properties of non-covalently dispersed single-walled carbon nanotube (SWCNTs) are well-suited for biological imaging and sensing applications due to intrinsic, photostable, and environmentally-sensitive photoluminescence in the near-infrared region. Appropriately functionalized nanotubes enter live cells and remain in the endolysosomal pathway. Here, we show that certain polymer-nanotube complexes can detect abnormal accumulations of lysosomal lipids in live cells, indicative of a family of diseases known as lysosomal storage disorders. Further, we show that the readout of the nanotube optical reporter is reversible in nature, and can be used to monitor the regression of disease upon pharmacological treatment.