(569h) Mussel-Inspired Injectable Gelatin-Methacryloyl Bioadhesive for Minimally Invasive Suregry

Noshadi, I. Sr., Northeastern University
Masoumi, A., Harvard University
Ashtiani Abdi, I., Harvard University
Nabavinia, M., Harvard University
Tamayol, A., Harvard University
Annabi, N., Northeastern University
Khademhosseini, A., Harvard University
Wet tissue adhesion required in many surgeries such as those for internal organs. The current surgical adhesives are not ideal. Developing surgical adhesives with strong wet tissue adhesion, controlled mechanical properties, and excellent biocompatibility has been a significant challenge. Herein, we report for the first time visible light crosslinkable catechol conjugated Gelatin (GelMAC) adhesive for internal surgeries. Compare to commercially available adhesive, GelMAC showed superior wet tissue adhesion, controlled mechanical properties and high in vitro Cytocompatibility. Three different ex-vivo animal models were used to evaluate the feasibility and effectiveness of GelMAC as minimally invasive sealants in the absence of any additional conventional surgical methods, such as suturing or stapling. Our results show that GelMAC is highly translational and could have broad impact on surgeries where surgical tissue adhesives and sealants are used.