(568e) Biomimetic Carrier-Mediated Membrane for Transport of Hydrophilic Molecules
In this work, the transport properties of boronic acid carrier immobilized lipid bilayer which is supported by orthogonally oriented hexagonally close packed (HCP) silica thin films on macroporous support will be examined. The effect of lipid bilayer preparation methods (in the form of pore enveloping, pore filling, tethering) on the barrier properties are first explored, as a good barrier is essential for detecting selective separation with the incorporation of biomimetic carriers in the bilayer. Next, the ability of immobilized boronic acid to facilitate the transport of active molecules through the membrane is demonstrated. The effect of factors like pH gradient, temperature (related to the lipid bilayer diffusivity) and the moleculeâ??s affinity for boronic acid are explored to improve the selectivity and permeability of this boronic acid-mediated membrane. In addition to boronic acid, other carriers immobilized in lipid bilayers are explored for the construction of selective biomimetic carrier-facilitated membranes.