(523d) Membrane Assisted Crystallization: Process Model and Antisovlent Crystallization Control for Continuous Pharmaceuticals Manufacture

Membrane assisted
crystallization: process model and antisovlent crystallization control for continuous pharmaceuticals manufacture

Xiaobin
Jiang*, Gaohong He*, Linghan Tuo

State Key Laboratory of Fine
Chemicals, Research and Development Center of Membrane Science and Technology,
School of Chemical Engineering, Dalian University of Technology, Dalian, P. R.
China

*Corresponding author: Email: xbjiang@dlut.edu.cn, hgaohong@dlut.edu.cn

Abstract

Membrane
assisted crystallization (MAC) has furnished a great progress in seawater
desalination, brine treatment, wastewater recovery and crystallization control
in recent decade, due to its advantages on utilizing low grade energy,
promoting nucleation, controlling crystallization, etc [1,2]. Systematically
frameworks and methods revolved MAC will be developed that can address the
challenges in seawater treatment, brine wastewater recovery, fine crystals
manufacture and biomolecular crystallization, etc [3].

In
this paper, the process model combined membrane assisted crystallization,
which involved the evaluation of the transmembrane flux and nucleation/growth
rate will be established. The advantages of MAC on supersaturation
degree control, nucleation kinetic and crystal size distribution modification
will be revealed and investigated. The impact of the desired membrane property
on the nucleation control was discussed in details.

On
the basis of authors previous work [4,5], the membrane distillation
crystallization is introduced to the antisolvent crystallization process to
validate the developed model and the impact of membrane participant mass
transfer process on continuous crystallization process control. The equivalent
supersaturated degree was introduced to evaluate the controlling accuracy of
MAC process and the stability of the control strategy. Due to the micrometer
scale porous channel of the membrane, the micro mixing can be significantly
improved and the mass tranfer control accuracy can be improved by 1 or 2
order of magnitudes compared to the existing droplet method with the millimeter
scale mixing.

As a
potential high accuacy control approach of antisolvent crystallizaiton, the MAC
assisted antisolvent crystallization can be utilized in continuous and scale-up
crystallization. These demands are especially significant in the area that have
strict requirements on excellent, steady crystal qualities and robust
crystallization control (pharmaceuticals crystallization, fine chemicals
preparation, e.g.).

In
addtion, these findings can drive the development of the comprehensive
understanding on the complex nucleation mechanism under the heterogeneous
chemical interface and confined environment. Further studies in this domain
will be important for furthering the landscape of MAC application and the
potential research results may provide conclusive evidence on the nucleation
mechanism in heterogeneous phases[7-8], which is the one of the core concerns
in nucleation theory.

Acknowledgment

This
work is supported by National Natural Science Foundation of China (Grant No.
21306017, 21527812), Program for Changjiang Scholars and Support Project of the
China Petroleum and Chemical Corporation (X514001).

References

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[2]
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Chabanon, E., Mangin, D., Charcosset, C.: Membranes and crystallization
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[7]
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(2011).

[8]
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Fig. 1 Schematic diagram of the antisolvent crystallization assisted by MAC
technology.