(502b) An Educational Matlab App for Pharmacokinetic/Pharmacodynamic Modeling of ACE-Inhibition
The mathematical models in this study describe the change in drug concentration over time as well as the Angiotensin II levels over time. The models use pharmacokinetic and pharmacodynamic relationships and were packaged into an interactive Graphical User Interface (GUI) in MATLAB. The students in the Summer Bridge Program used the app to design optimal pharmaceutical dose amounts and frequencies needed for lowering blood pressure using two different ACE inhibitors (Benazapril and Cilazapril) in patients with either normal or impaired kidney function. Plots were generated for the drug and Angiotensin II concentrations over time. These plots were analyzed and evaluated by the students to make an educated decision as to the optimal dosage conditions for their virtual patient. In addition to the use of the simulation, the students participated in activities to introduce basic calculus, differential equations, and coding to give the students a better understanding of the simulation functionality and its connections to their basic engineering and mathematics coursework.
The students were assigned specific drug types and virtual patient kidney functions and asked to design the optimal dosage and frequency for those cases. After they decided on a final design, the students were asked to create a short report and presentation to convey their results and learning outcomes to their peers. Overall, the students seemed to enjoy seeing pharmaceutical applications of chemical and biomedical engineering as well as having the aspect of creative decision making throughout the project.
Through use of the MATLAB app, students practiced open-ended engineering design, connected calculus and coding to solve realistic engineering problems, constructed a scientific presentation, practiced public speaking, and gave feedback on peersâ?? presentations. This app is a useful tool for students to gain familiarity with chemical and biomedical engineering concepts including design, without having significant background training.