(284g) Continuous Co-Crystallization of Novel Theophylline and 4-Aminobenzoic Acid Co-Crystals from Twin Screw Extrusion
AIChE Annual Meeting
2016 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Continuous Processing in the Manufacture of Pharmaceuticals: Drug Substance (In memory of Tom LaPorte)
Tuesday, November 15, 2016 - 10:20am to 10:42am
High-shear granulation and twin screw extrusion, have recently been used for co-crystal preparation. These methods are environmentally friendly as they avoid, or minimise, the use of organic solvents [2 & 5]. Twin screw extruder mediated co-crystallisation is a promising processing technique for continuous co-crystallisation. Although twin screw extruder mediated co-crystallisation has been reported with various primary experimental parameters (screw geometry, temperature, feed rate and the RPM of the screws) that can affect co-crystal conversion, information on the impact of processing parameters processing temperature (eg. at eutectic temperature and room temperature), shear dependent crystallization, residence time and addition of organic solvents is less available. Therefore to enhance understanding of continuous co-crystallisation process in the present study the effect of key extrusion processing parameters that influence extent of conversion to the co-crystals has been studied. A Theophylline-4-Aminobenzoic acid novel co-crystal forming system was selected for the study. Appropriate stoichiometric ratios of Theophylline-4-Aminobenzoic acid were prepared. Co-crystallization of novel co-crystal system was carried out in a co-rotating 12 mm Hybrid Mini-Extruder (Three-Tec GmbH, Switzerland) with a length-to-diameter ratio of 40:1. The extrudates were mainly characterised by powder X-ray diffraction (PXRPD), differential scanning calorimetry (DSC), and in vitro drug release studies. As shown parameters had a significant influence on co-crystallization process, consequently they are important to consider in co-crystallization process. Finally twin screw extruder mediated co-crystallisation can be considered easy, cheap, scalable, and environmentally friendly for continues co-crystallization.
Key words: continuous co-crystallisation, twin screw extrusion, Theophylline-4-Aminobenzoic acid.
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