(233t) Continuous Manufacturing of Co-Crystals in Twin Screw Extruder: A Case Study
- Conference: AIChE Annual Meeting
- Year: 2016
- Proceeding: 2016 AIChE Annual Meeting
- Group: Pharmaceutical Discovery, Development and Manufacturing Forum
Monday, November 14, 2016 - 3:15pm-5:45pm
The main aim of this study is to investigate and develop novel processes for continuous pharmaceutical processing of co-crystals. Wet granulation was chosen as a manufacturing method since it combined synthesis and granulation in a single continuous operation step. A 12 mm twin screw extruder (Three-Tec, Switzerland) with a length-to-diameter ratio of 40 was used for the manufacturing of the granules.A novel Theophylline-Aspirin (THP-ASP) model system was selected for the study. The effects of different process parameters (feed rate, screw speed, liquid-to-solid ratio) and formulation parameters (API and co-former ratio) on the final granules properties and the extent of conversion were investigated. Particle size distribution was analysed using Microtrac particle size analyser. The solid state form of the final granules was characterised with various techniques, including DSC, and PXRD.