(228bl) Engineering of Microbial Cell Factories for Biobased Chemicals Production
AIChE Annual Meeting
2016
2016 AIChE Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Poster Session: Bioengineering
Monday, November 14, 2016 - 3:15pm to 5:45pm
The Metabolic Engineering Research Laboratory in Singapore is focused on addressing these challenges through the design and engineering of recombinant microorganisms. In this presentation, I will highlight our accomplishments including: (a) deconstruction of cellulose through engineering a Saccharomyces cerevisiae pentafunctional minicellulosome system with enhanced cellulose degradation capabilities, which can also be applied as a cellulase engineering platform, (b) metabolic engineering of microbial cell factories for the production of biochemicals, such as n-butanol and adipic acid, and (c) development of an efficient technological platform for the integration of large genetic pathways and circuits (up to 24 kb) into the yeast genomes to create genetically stable production hosts.