(184h) Effects of Nanoscale Geographies on Osseointegration and Bacterial Growth Conference: AIChE Annual MeetingYear: 2016Proceeding: 2016 AIChE Annual MeetingGroup: Liaison FunctionsSession: Undergraduate Research Forum II Time: Monday, November 14, 2016 - 2:15pm-2:30pm Authors: Nguyen, C. Titanium has been widely used in bone implants, owing to its near-ideal mechanical strength and relative biocompatibility, but often necessitates repeated surgeries due to infection and poor osseointegration. Implants can be roughened with porous coatings to encourage cell integration, and with nanoscale titanium texturing, there have been results of improved osseointegration and decreased bacterial presence. It is known that nanoscale features improve bone growth and reduce bacterial adherence, but unknown exactly which structure of this texturing is most conducive to this. From previous bacterial experiments with the titanium samples, there appeared to be no strong correlation between the colony forming units of seeded S. aureus and the sample roughness, which suggested that the current method of quantifying roughness with a specific value may be flawed. Comparison of atomic force micrographs of samples alongside their â??roughnessâ? values evidenced that a specific value did not imply a particular nanotexturing; some features displayed similar roughnesses yet possessed dissimilar surface features. Investigation of these nanogeographical differences demonstrated that samples with more dense, evenly sized nanosurfaces resulted in greater bacterial inhibition than those with more varied nanofeatures. Regardless, that all nanostructured samples exhibited strong antibacterial properties with little detrimental effect on human osteoblasts.