(184h) Effects of Nanoscale Geographies on Osseointegration and Bacterial Growth
and relative biocompatibility, but often necessitates repeated surgeries due to infection and
poor osseointegration. Implants can be roughened with porous coatings to encourage cell
integration, and with nanoscale titanium texturing, there have been results of improved
osseointegration and decreased bacterial presence.
It is known that nanoscale features improve bone growth and reduce bacterial adherence, but
unknown exactly which structure of this texturing is most conducive to this. From previous
bacterial experiments with the titanium samples, there appeared to be no strong correlation
between the colony forming units of seeded S. aureus and the sample roughness, which
suggested that the current method of quantifying roughness with a specific value may be
flawed. Comparison of atomic force micrographs of samples alongside their â??roughnessâ? values
evidenced that a specific value did not imply a particular nanotexturing; some features
displayed similar roughnesses yet possessed dissimilar surface features. Investigation of these
nanogeographical differences demonstrated that samples with more dense, evenly sized
nanosurfaces resulted in greater bacterial inhibition than those with more varied nanofeatures.
Regardless, that all nanostructured samples exhibited strong antibacterial properties with little
detrimental effect on human osteoblasts.