(6p) Systems Biology Approaches to Develop Precision Therapeutic Approaches to Overcome Drug Resistance in Cancer | AIChE

(6p) Systems Biology Approaches to Develop Precision Therapeutic Approaches to Overcome Drug Resistance in Cancer


Fallahi-Sichani, M. - Presenter, Harvard Medical School

My goal is to direct a research program that combines multiplex biochemical measurement, single-cell analysis and novel multi-scale and network-level computational modeling to address fundamental and clinically significant challenges in cancer biology: (i) relating drug action at the molecular scale to phenotypes at the cellular and tissue (tumor) levels, (ii) understanding signaling mechanisms involved in drug-induced adaptive responses that lead to submaximal cell killing and ultimately drug resistance in patients, (iii) developing predictive mathematical models that guide development of safe, effective and personalized therapeutic approaches to overcome drug resistance. My PhD background in multi-scale computational modeling and signal transduction, postdoctoral training in cancer cell signaling and systems pharmacology, strong publication record and successful fellowship and grant applications have all prepared me to successfully accomplish the goals outlined above.


(2012) PhD, Chemical Engineering, University of Michigan, Ann Arbor, MI

(2009) MSc, Chemical Engineering, University of Michigan, Ann Arbor, MI

(2007) BSc/MSc (Integrated), Biotechnology, University of Tehran, Iran

Research/Work Experience:

(2012-Present) LSRF Postdoctoral Fellow in Systems Biology, Harvard Medical School (Advisor: Dr. Peter Sorger)

(2007-2012) Graduate Student Research Assistant, Chemical Engineering, University of Michigan, Ann Arbor (Advisors: Dr. Jennifer Linderman and Dr. Denise Kirschner)

Grants and Honors:

(2015) NIH K99 Pathway to Independence Award, NCI (selected for funding in Aug 2015)

(2013-Present) Life Sciences Research Foundation (LSRF) Postdoctoral Fellowship

(2012) Distinguished Young Scholars Seminar Speaker, University of Washington, Seattle

(2011) Richard and Eleanor Towner Prize for Outstanding PhD Research Award, University of Michigan

(2011) Rackham Predoctoral Fellowship, University of Michigan

(2010) Phi Kappa Phi Graduate Award

(2009) Rackham International Student Fellowship, University of Michigan

Conference Awards:

(2015) American Association for Cancer Research (AACR) Scholar-in-Training Award

(2014) Outstanding Poster Award, FEBS-EMBO 2014 Conference, Paris, France

(2013) Systems Biology of Human Disease Conference Travel Award, Germany, Heidelberg

(2011) 5thq-bio Conference in Cellular Information Processing Travel Award, Santa Fen, NM

 Selected Publications:

1) Lin JR, Fallahi-Sichani M, Sorger PK. Highly multiplexed high-throughput imaging of single-cell using CycIF cyclic immunofluorescence (in revision at Nature Communications).

2) Fallahi-Sichani M, Moerke NJ, Niepel M, Zhang T, Gray NS, Sorger PK. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis, Molecular Systems Biology (2015) 11:797.

3) Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK. Metrics other than potency reveal systematic variation in responses to cancer drugs, Nature Chemical Biology (2013) 9:708-14.

4) Kirschner DE, Hunt CA, Marino S, Fallahi-Sichani M, Linderman JJ. Tunable resolution as a systems biology approach for multi-scale, multi-compartment computational models, WIREs Systems Biology and Medicine (2014) 6:289-309.

5) Fallahi-Sichani M, Kirschner DE, Linderman JJ. NF-kappaB signaling dynamics play a key role in infection control in tuberculosis, Frontiers in Physiology (2012) 3:170.

6) Fallahi-Sichani M, Flynn JL, Linderman JJ, Kirschner DE. Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability, Journal of Immunology (2012) 188:3169-78.

7) Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multiscale computational modeling reveals a critical role for TNF-a receptor 1 dynamics in tuberculosis granuloma formation, Journal of Immunology (2011) 186:3472-83.

8) Fallahi-Sichani M, Schaller MA, Kirschner DE, Kunkel SL, Linderman JJ. Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma, PLoS Computational Biology (2010) 6:e1000778.

9) Fallahi-Sichani M, Linderman JJ, Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: A computational study, PLoS ONE (2009) 4:e6604.


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