(433c) Ultrastable Core-Shell Structured Nanoparticles Directly Made from Zwitterionic Polymers
Colloid stability is crucial for nanoparticles (NPs) to remain nano-effects in various functioning media. Various methods had been utilized to modify hydrophobic core to render nanoparticle with colloid stability, especially in bio-related environment. However, these methods were either involving complex chemical synthesis or low in efficiency due to unpredicted NP surface environment. Here, rather than modify the nanoparticle, for the first time we directly make self-assembled core-shell nanoparticles from zwitterionic polymer using green chemistry. Zwitterionic polymers are novel generation biomaterials showing excellent non-fouling properties. NPs protected by zwitterionic polymers have been found with long blood circulation characteristics and particularly suitable for drug delivery applications. Characterization confirmed the core-shell structure and resulting zwitterionic nanoparticles had superior colloid stability in highly concentrated protein/PBS buffer solution and even freeze-drying condition. This work initiates a new concept of directly making stable nanoparticles through green chemistry and will inspire new strategy and green chemistry to be applied in nanotechnology.