(362a) Recent Advancement in Nanostructured Enzyme Catalysts for Chemical Synthesis Conference: AIChE Annual MeetingYear: 2015Proceeding: 2015 AIChE Annual MeetingGroup: Nanoscale Science and Engineering ForumSession: Nanoscale Science and Engineering in Biomolecular Catalysis II Time: Tuesday, November 10, 2015 - 12:30pm-1:00pm Authors: Ge, J., Tsinghua University Lu, D., Tsinghua University Liu, Z., Key Lab of Industrial Biocatalysis, Ministry of Education, Tsinghua University For decades we have been working on novel approaches incorporating enzyme into nanostructures presenting high activity, high stability and ease of recovery and reuse. It is observed, also by our colleagues, that accommodation in a nanometer environment with tailor-made surface properties often lead to greatly improved stability and activity of the confined enzyme, particularly under adverse conditions such as an elevated temperature and the presence of organic solvents. This presentation will summarize our recent progress in the synthesis of nanostructured enzyme catalysts, in particular, the binary enzyme catalysts that performed cascade reactions. We will also show our efforts towards establishing a molecular insight of the interaction among nanostructures and confined enzymes and their impacts on the enzymatic reaction kinetics and process through a complementary input from multi-scale molecular simulation, multidimensional structural characterization and reaction process analysis. References:1. Wu XL, Ge J*, Zhu JY, Yong Y and Liu Z*, Chem Commun, 2015, DOI: 10.1039/C5CC01776A2. Wang R, Zhang YF, Ge J* and Liu Z*, RSC Adv., 2014, 4, 403013. Lyu FJ, Zhang YF, Zare RN, Ge J* and Liu Z*, Nano Lett., 2014, 14, 5761.4. Li ZX, Zhang YF, Su YC, Ouyang PK, Ge J,* and Liu Z*, Chem Commun., 2014, 50,12465.5. Zhu JY, Zhang YF, Lu DN, Zare RN, Ge J,* and Liu Z*, Chem Commun., 2013, 49, 6090.