(146h) Thermodynamic Properties of Monoclonal Antibody Solutions
AIChE Annual Meeting
2015
2015 AIChE Annual Meeting Proceedings
Computational Molecular Science and Engineering Forum
In Honor of Stanley Sandler II
Monday, November 9, 2015 - 2:15pm to 2:30pm
Monoclonal antibodies (mAbs) are a class of proteins that represent the largest single group of protein drugs produced by the pharmaceutical and biotechnology industries; annual sales of mAbs now exceed $100 billion. All mAbs share extensive common structural features, but very small local changes in structure, including substitution of a small number (1-3) of amino acids, can lead to dramatic changes in thermodynamic and transport properties. This presentation will cover examples of such changes via a variety of different measurements, with a special focus on the effects of small structural changes. These include effects on mAb self-interactions, oligomerization, phase behavior, and viscosity. Potential molecular bases for this sensitivity will be examined.