(621d) Predictive Screening of Column Pair Combinations for Two-Dimensional Liquid Chromatography

Authors: 
Lindsey, R. K. - Presenter, University of Minnesota
Stoll, D. R., Gustavus Adolphus College
Carr, P. W., University of Minnesota
Siepmann, J. I., University of Minnesota

Predictive Screening of Column Pair Combinations for Two-dimensional Liquid Chromatography

Rebecca K. Lindsey,1 Dwight R. Stoll,2 Peter W. Carr,1 and J. Ilja Siepmann1,3†

1Department of Chemistry and Chemical Theory Center, University of Minnesota, Minneapolis, MN 55455-0431
2Department of Chemistry Gustavus Adolphus College, Saint Peter, Minnesota 56082
3Department of Chemical Engineering and Materials Science University of Minnesota, Minneapolis, MN 55455-0431

Two-dimensional liquid chromatography (2DLC) is a powerful separation technique that employs a second column to further separate fractions taken from the first column; when utilized in an on-line fashion, 2DLC can result in much higher total peak capacities than are achievable with a single column. This computational work addresses the significant challenge of selecting an optimal column pair from the N2 possible combinations (order matters in the on-line approach) by presenting a predictive screening method for column pair selection, and provides insight into the defining characteristics of a good column pair.

Corresponding Author. E-mail: siepmann@umn.edu

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