(404b) Folding By Design
AIChE Annual Meeting
2014
2014 AIChE Annual Meeting
Nanoscale Science and Engineering Forum
Self and Directed Assembly at the Nanoscale
Tuesday, November 18, 2014 - 3:30pm to 3:45pm
A form of self-assembly, "self-folding'' presents an alternative approach to the creation of reconfigurable, responsive materials with applications ranging from robotics to drug design. However, the complexity of interactions present in biological and engineered systems that undergo folding makes it challenging to isolate the main factors controlling their assembly and dis-assembly. Here we use computer simulations of simple, minimalistic self-foldable structures and investigate their stochastic folding process. By dynamically accessing all the states that lead to, or inhibit, successful folding, we show that the mechanisms by which general stochastic systems can achieve their "native'' structures can be identified and used to design rules for optimized folding propensity.