(397az) Application of a Smart Antimicrobial Coating in Facilities to Combat Indirect Infection Conference: AIChE Annual MeetingYear: 2013Proceeding: 2013 AIChE Annual MeetingGroup: Nanoscale Science and Engineering ForumSession: Poster Session: Nanoscale Science and Engineering Time: Tuesday, November 5, 2013 - 6:00pm-8:00pm Authors: Sim, V., The Hong Kong University of Science and Technology Leung, H. H. Yeung, K. L., The Hong Kong University of Science and Technology The World Health Organization (WHO) has stated that indirect transmission is one of the major means of disease transmission. Indirect transmission refers to the transfer of an infectious agent via a contaminated object or person. Inanimate surface isconsidered as a common medium that acts as a reservoir for microorganisms to thrive in until the next user touch it. An antimicrobial coating containing antimicrobial agents has been developed to inhibit the survivability and growth of microorganisms on surfaces. In this work, chlorine dioxide was encapsulated with polymer. The water in oil in water encapsulation provides a slow and controlled release of chlorine dioxide that is responsive to touch. The release of antimicrobial agent will be faster upon an increase in temperature and moisture. Therefore, the designed coating can provide both contact killing and release killing properties. In laboratory testing, the antimicrobial coating can obtain a reduction of 4log10bacteria within 1 min of contact time for gram negative and gram positive bacteria.The bactericidal property of the coating can last for at least one month. The antimicrobial coating is also able to kill several Multidrug Resistance Organisms(MDRO), including Vancomycin, Methicillin-resistant Staphylococcus Aureus (MRSA). The antimicrobial coating has undergone field testing in hospital settings, including an Intensive Care Unit and an orthopedic ward in a local hospital in Hong Kong. The result showed that the microbial contamination on inanimate surfaces has been significantly reduced compared surfaces routinely cleaned by bleach solution. Our results show that the antimicrobial coating is a potent agent to reduce surfacecontamination, and therefore, a possible solution to reduce disease transmission.