(601h) The Effect of Interdroplet Spacing and Droplet Volume On the Dissolution Profiles of Ink-Jet Printed Dopamine Hydrochloride

We propose to utilize Drop-on-Demand technology to manufacture transdermal dosage forms  in an innovative and systematic approach. The primary goal is to fabricate a novel dosage form where two or more drugs can be printed onto the same layer to achieve desired efficacy effects.  Additionally, the release profile can be manipulated and predicted with greater accuracy.   Previous research has detailed that manipulation of substrate properties can be used to control the morphology of the API deposits and obtain API forms ranging from amorphous to crystalline structures. Data analysis also indicates that pattern inter-droplet spacing and droplet volume affect the dissolution rate.  This study establishes the relationships between the API and polymer film properties, kinetics of the evaporation process, final stain morphology, solubility properties of the fabricated dosage, and API dissolution. Ultimately this research will enable the development of scientific fundamentals which allow us to accurately create novel API dosage forms where the final droplet structure exists as defined two and three dimensional architecture with a controllable release profile.