(402f) Effect of Paddle Shape On Flow of Powder Through Feed Frames On Rotary Tablet Presses

Effect of paddle shape on flow of powder through feed
frames on rotary tablet presses

G. Singh*, J. Givand**, P. Rajniak**, R. Chern**,
S.D. Reynolds** and I.C. Sinka*

*Department of Engineering, University of Leicester,
University Road, Leicester, LE1 7RH, UK

**Merck, Sharp & Dohme, Sumneytown Pike, West Point, PA19486, USA

A commercial scale high speed rotary tablet press can
produce in excess of 0.5 million pharmaceutical tablets per hour. This involves
the same number of die fill operations, which must be executed consistently to
ensure weight and content uniformity from tablet to tablet. High productivity
can only be achieved if the formulation of the powder and the selection of
process parameters are optimised.

Die fill is a complex and dynamic process and
consists of a number of distinct stages that present unique features: delivery
of the powder to the press (in batches or continuously), powder flow from
hopper to feed frame, powder flow through feed frame to die opening, and die
fill. In this paper we examine the flow of powders through a lab scale rotary
feeder which was developed at the University of Leicester to explore
the mechanisms present in the feed frames of rotary tablet presses. The feeder
pictured below consists of an inlet hopper, a disk shaped frame housing a
paddle wheel and a powder outlet.

The flow regimes were examined for a poorly flowing
placebo formulation and the following parameters were considered:

·       
Paddle wheel speed: 25, 50, ?, 400 rpm

·       
Outlet diameter: 5, 10, 15, 20 mm

·       
Shape of paddle wheel spoke cross section:
round, square and inclined

It is shown that the powder delivery
is not always as continuous as the figure below implies and that poor flowing
materials can perform surprisingly well under the conditions imparted by the
rotary feeder. The results are quantified in terms of mass flow rate through
the feeder, which increases and saturates as the freed frame speed is
increased. It was interesting to note, however, that the mass flow rate per
unit area of the outlet can increase or decrease as the outlet diameter is
reduced, depending on powder. For all cases a significant effect of the shape
of the paddle cross section was observed.

Experimental
set-up of lab scale rotary feeder