(393a) Enantioselective Properties of Chiral Surface Modified Gold Nanoparticles and Their Variation with Temperature, Wavelength, and Particle Size

Khosla, N., Carnegie Mellon University
Downey, P., Colorado School of Mines

Surfaces of chemically synthesized gold nanoparticles were modified with both L and D enantiomers of glutathione and cysteine to make them chiral.  The chirality of these nanoparticles was examined by using various chiral probe molecules such as  2-Butanol, glucose, tartaric acid and alanine. We have used simple polarimetery to test the chirality at  25 degrees celsius and 436 nm wavelength.  Our work shows that L-cysteine is better ligand for adsorbtion of the probe molecules than L-glutathione. L-cysteine coated Au nanoparticles show larger enantioselective separation in comparison to L-glutathione coated Au nanoparticles.  In addition, glucose has highest enantioselective separation in comparison to 2-butanol, tartaric acid, and alanine.  Thus we see that this method for separating chiral molecules on the surface of chirally modified gold nanopartices works with different efficacy for a range of proble molecules.  Furthermore, these effects are altered depending on which ligand was used to modfy the gold nanoparticle surface.
See more of this Session: Poster Session: Nanoscale Science and Engineering

See more of this Group/Topical: Nanoscale Science and Engineering Forum