(213b) Particle-Polymer Interaction in Hydrogels

The presence active pharmaceutical ingredient (API) in biopolymer network impacts the film formation and plays role in control release. One of the most important factors that affect the formation of polymer matrix is the interaction of polymer – surfactant – API particles. The film formation of several biopolymers loaded API has been investigated. Dynamic light scattering technique is applied to analyze particle size of API particles and their zetapotential in different film precursor solutions. SEM is used to reveal the arrangement of API particle in the film matrix. The interaction of polymer – polymer and polymer – surfactant in these mixtures is analyzed by surface tension and rheology measurements. A sensitive gravimetric system is exploited to detail the drying kinetic of those considered mixtures. Our results show that, the surfactant plays a role in adsorption behavior of polymer on API particles when API is loaded in a polymeric film precursor solution while polymer-polymer interaction is key factor in the formation of binary polymeric network