(548d) Experimental Investigation of Crystal Shape Evolution During Growth and Dissolution
AIChE Annual Meeting
Wednesday, October 19, 2011 - 1:45pm to 2:10pm
Controlling crystal morphology is a hot topic in current research on crystalline materials for diverse industrial applications. In this connection, experimental detection of polymorphs through on-line measurement of crystal morphology in a crystallizer is a problem of crucial interest. XRD and Raman Spectroscopy are generally accepted as a primary method to identify polymorphs. We present evidence of a new, strikingly simple and inexpensive method of identifying polymorphs through computer-aided analysis of images produced with a Confocal microscope. This methodology has the following features.
- A software with an automated program for polymorph detection integrated with a Confocal microscope which can be used for on-line monitoring and control of particle shape, size and polymorph content.
- Different polymorphs can be identified by recognizing inter-planar angular patterns specific to a given polymorph. It yields the absolute amounts of different polymorphs present in a population of crystals.
- It has the potential for on-line measurement of 2D and 3D crystals of complex shapes.
Consequently, this methodology can:
- Replace currently used FBRM (focused-beam reflectance measurement), digital video imaging and microscopy based sensors that have limitations with real shapes.
- Eliminate the need for multiple sensors currently used in industry.